| Annotated protein: | SLIT and NTRK-like family, member 1. Gene symbol: SLITRK1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3Z8D8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLITRK1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse organization (GO:0050807) |
| Synapse type(s): | hippocampus, glutamatergic hippocampus, GABAergic |
| Annotated paper: | Beaubien F, et al. "Slitrk1 is localized to excitatory synapses and promotes their development" Sci Rep. 2016 Jun 7;6:27343 PMID:27273464 |
| Figure(s): | Fig.2, 3 |
| Annotation description: | Fig.2: "Overexpression of Slitrk1 and Slitrk2 in cultured neurons increases the amount of presynaptic excitatory and inhibitory contacts" Fig.3: "Knockdown of Slitrk1 by shRNA in cultured neurons reduces synapse density" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2619 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |