Annotated protein:	Flotillin-2 (Reggie-1) (REG-1). Gene symbol: FLOT2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9Z2S9
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SynGO gene info:	SynGO data @ FLOT2
Ontology domain:	Cellular Component
SynGO term:	anchored component of presynaptic active zone membrane (GO:0099029)
Synapse type(s):	brain, glutamatergic
Annotated paper:	Boyken J, et al. "Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses" Neuron. 2013 Apr 24;78(2):285-97 PMID:23622064
Figure(s):	fig. 5, supplementary tables S1 and S5
Annotation description:	>10fold-enriched in docked SV fraction (fig. 5) 20/3/2017 Pim - Because enriched in AZ and not in free SV protein is presumably localized to the AZ, and not in co-purifying SVs. -According to uniprot Flot-2 has a lipid anchor justifying the "anchored component of ...." term.
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Antibody (detection)
Evidence tracking, Experiment Assay:	Mass-spectrometry Biochemical fractionation (generic)
Annotator(s):	Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414)
Lab:	Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
Additional literature:	Both Flotillins seem to be localized pre- and postsynaptically. Suzuki et al . Association of membrane rafts and postsynaptic density: proteomics, biochemical, and ultrastructural analyses. J Neurochem. 2011 Oct;119(1):64-77 @ PMID:21797867 Both Flotillins seem to be localized pre- and postsynaptically. Peng et al (2004) J Biol Chem 279:21003-21011 @ PMID:15020595
SynGO annotation ID:	261
Dataset release (version):	20231201
View annotation as GO-CAM model: