Annotated protein:	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (Synaptic adhesion-like molecule 4). Gene symbol: LRFN3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: B0BNK7
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SynGO gene info:	SynGO data @ LRFN3
Ontology domain:	Cellular Component
SynGO term:	integral component of presynaptic active zone membrane (GO:0099059)
Synapse type(s):	hippocampus cerebellum olfactory bulb
Annotated paper:	Seabold GK, et al. "The SALM family of adhesion-like molecules forms heteromeric and homomeric complexes" J Biol Chem. 2008 Mar 28;283(13):8395-405 PMID:18227064
Figure(s):	Fig 7
Annotation description:	Fig.7: "Ultrastructure of native SALM4 interactions in the brain using 10-nm immunogold labeling" - "In immunogold-labeled sections from the hippocampus of P10 rats, and hippocampus, cerebellum, and olfactory bulb of young adult rats, SALM4 was localized largely to the cell membrane of neuronal processes (Fig. 7). At synapses, these included both the synaptic and extrasynaptic membranes on both presynaptic and postsynaptic sides, as well as the cell membrane of other structures such as neuron somas (Fig. 7D) and myelinated axons (Fig. 7H). In many cases, plasma membrane-associated gold could be found on both sides of adjacent membrane appositions (Fig. 7, A-D, F, and G). " - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Antibody (detection)
Evidence tracking, Experiment Assay:	Electron Microscopy
Annotator(s):	Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584)
Lab:	Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea
SynGO annotation ID:	2605
Dataset release (version):	20231201
View annotation as GO-CAM model: