Annotated protein: | Glypican 6. Gene symbol: GPC6. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: A0A096MJY1 |
antibody wiki: | |
SynGO gene info: | SynGO data @ GPC6 |
Ontology domain: | Biological Process |
SynGO term: | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0098696) |
Synapse type(s): | retina, glutamatergic |
Annotated paper: | Allen NJ, et al. "Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors" Nature. 2012 May 27;486(7403):410-4 PMID:22722203 |
Figure(s): | Fig.3, supplemental figure 8 |
Annotation description: | GPC6 is sufficient to increase surface clustering of GluA1 AMPA receptors and to induce structural synapse formation. 21/2/2018 Pim - GPC6 is a protein secreted by astrocytes. |
Evidence tracking, Biological System: | Cultured neurons |
Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
SynGO annotation ID: | 2601 |
Dataset release (version): | 20231201 |
View annotation as GO-CAM model: |