Annotated protein:Glypican 6. Gene symbol: GPC6. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: A0A096MJY1
antibody wiki:
SynGO gene info:SynGO data @ GPC6
Ontology domain:Biological Process
SynGO term:regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0098696)
Synapse type(s):retina, glutamatergic
Annotated paper:Allen NJ, et al. "Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors" Nature. 2012 May 27;486(7403):410-4 PMID:22722203
Figure(s):Fig.3, supplemental figure 8
Annotation description:GPC6 is sufficient to increase surface clustering of GluA1 AMPA receptors and to induce structural synapse formation.

21/2/2018 Pim
- GPC6 is a protein secreted by astrocytes.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:RNAi / shRNA
Over-expression
Evidence tracking, Experiment Assay:Confocal
Whole-cell patch clamp
Annotator(s):Hwajin Jung (ORCID:0000-0001-6194-9648)
Eunjoon Kim (ORCID:0000-0001-5518-6584)
Lab:Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea
SynGO annotation ID:2601
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology