Annotated protein:Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta). Gene symbol: DGKB. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6NS52
antibody wiki:
SynGO gene info:SynGO data @ DGKB
Ontology domain:Biological Process
SynGO term:regulation of postsynapse organization (GO:0099175)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Shirai Y, et al. "Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function" PLoS One. 2010 Jul 15;5(7):e11602 PMID:20657643
Figure(s):fig 4, 5, 6, 7, 9
Annotation description:Impairment of neuronal branching and spine formation in the primary cultured hippocampal neurons in DGKB KO mice.
DGKB-induced branching and spine formation in the primary cultured hippocampal neurons.
Abnormality of synapse density and phosphatidic acid/diacylglycerol levels in the hippocampus of DGKB KO mice.

21/2/2018 Pim
Fig.5: "Impairment of spine formation in the primary cultured hippocampal neurons from DGKβ KO mice."
Fig.6: "DGKβ-induced branching and spine formation in the primary cultured hippocampal neurons from WT mice."
Fig.7: "Rescue of impaired branching and spine formation in the primary cultured hippocampal neurons from KO mice by DGKβ overexpression"
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Over-expression
Evidence tracking, Experiment Assay:Electron Microscopy
Confocal
Annotator(s):Hwajin Jung (ORCID:0000-0001-6194-9648)
Eunjoon Kim (ORCID:0000-0001-5518-6584)
Lab:Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea
SynGO annotation ID:2598
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology