Annotated protein:	Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7). Gene symbol: SLC16A7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63344
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SynGO gene info:	SynGO data @ SLC16A7
Ontology domain:	Cellular Component
SynGO term:	integral component of postsynaptic density membrane (GO:0099061)
Synapse type(s):	hippocampus, glutamatergic
Annotated paper:	Bergersen LH, et al. "Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking" Cereb Cortex. 2005 Apr;15(4):361-70 PMID:15749979
Figure(s):	Fig 2
Annotation description:	Figure 1 Legend: -Literal: "Localization of MCT2 and GluR2/3 subunits at Schaffer collateral/commissural fibre synapses in rat CA1 stratum radiatum by immunogold labeling. (A--D) Electron micrographs showing double labeling for MCT2 (small gold particles) and GluR2/3 subunits (large gold particles). Note the specific localization of MCT2 and GluR2/3 subunits in a restricted portion of the synaptic membrane at synapses (open white arrowheads) between Schaffer collateral/commissural fibre terminals (scct) and dendritic spines (s) corresponding to the postsynaptic density area, as well as in vesicular organelles (open arrowheads) within spines. Scale bars: 100 nm." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Antibody (detection)
Evidence tracking, Experiment Assay:	Electron Microscopy
Annotator(s):	Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306)
Lab:	Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra
SynGO annotation ID:	2592
Dataset release (version):	20231201
View annotation as GO-CAM model: