| Annotated protein: | SLIT and NTRK-like protein 3. Gene symbol: SLITRK3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q810B9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLITRK3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | hippocampus, GABAergic |
| Annotated paper: | Takahashi H, et al. "Selective control of inhibitory synapse development by Slitrk3-PTPdelta trans-synaptic interaction" Nat Neurosci. 2012 Jan 29;15(3):389-98, S1-2 PMID:22286174 |
| Figure(s): | Fig.2, Suppl.Fig.3 |
| Annotation description: | Figure 2: "Recombinant Slitrk3 localizes to inhibitory postsynaptic sites" - "A majority of YFP-Slitrk3 puncta colocalized well with clusters of the inhibitory postsynaptic scaffold gephyrin apposed to VGAT (Fig. 2a) and with GABA receptor γ2 clusters apposed to VGAT (Fig. 2b), but hardly colocalized with excitatory postsynaptic scaffold PSD-95 or VGLUT1 (Fig. 2c,d). The presence of YFP-Slitrk3 puncta in dendrites but not axons of transfected neurons indicated postsynaptic and not presynaptic accumulation (Supplementary Fig. 3)." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2588 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |