| Annotated protein: | SLIT and NTRK-like protein 1. Gene symbol: SLITRK1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q810C1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLITRK1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Beaubien F, et al. "Slitrk1 is localized to excitatory synapses and promotes their development" Sci Rep. 2016 Jun 7;6:27343 PMID:27273464 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1: "Localization of Slitrk1 at the synapse" - "These analyses revealed that a portion of Slitrk1 protein is found in synaptic membrane fractions (Fig. 1d)" - "Note that Slitrk1 is detected in synaptic fractions including P2, P2* and the postsynaptic densities (PSD)." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2586 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |