| Annotated protein: | Voltage-dependent calcium channel gamma-4 subunit (Neuronal voltage-gated calcium channel gamma-4 subunit) (Transmembrane AMPAR regulatory protein gamma-4) (TARP gamma-4). Gene symbol: CACNG4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9JJV4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CACNG4 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor activity (GO:0098962) |
| Synapse type(s): | cerebellum, glutamatergic |
| Annotated paper: | Cho CH, et al. "Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents" Neuron. 2007 Sep 20;55(6):890-904 PMID:17880893 |
| Figure(s): | Figure 7 |
| Annotation description: | TARP γ-4 modulates the decay of synaptic AMPAR currents. Fig. 7: Overexpression of stargazin (stg, TARP γ-2) or TARP γ-4 in cultured cerebellar granule cells from stg mutant (stg/stg) mice restored AMPAR-mediated synaptic responses. The amplitude and frequency of mEPSCs in stg/stg cells transfected with TARP γ-4 were ~50% of WT. The decay of mEPSCs and weighted decay constants were slower in TARP γ-4 expressing neurons compared to TARP γ-2 or WT cells. The differential slowing of the decay of mEPSCs by TARP γ-4 in neurons was similar to its effect on slowing of deactivation decays for GluR1 channels in heterologous cells, "demonstrating that the isoform-specific modulation of gating kinetics characterized here is relevant to synaptic transmission in neurons." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Hana Goldschmidt (ORCID:0000-0002-5676-366X) Richard Huganir (ORCID:0000-0001-9783-5183) |
| Lab: | Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA and Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA |
| Additional literature: | overexpression of stargazin in cultured cerebellar granule cells from stargazer mice restores AMPA receptor-mediated synaptic responses @ PMID:11140673 PMID:12771129 |
| SynGO annotation ID: | 2580 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |