| Annotated protein: | Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor). Gene symbol: GHSR. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O08725 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GHSR |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Berrout L, et al. "Ghrelin promotes reorganization of dendritic spines in cultured rat hippocampal slices" Neurosci Lett. 2012 May 16;516(2):280-4 PMID:22516464 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1: "Ghrelin was applied for 60 min (Fig. 1A3 and C). In control slices, the average spine density was 0.302/unit area ± 0.039 SEM (n = 30 images taken from 10 slices) (Fig. 1A2). Ghrelin (200 nM) increased the average spine density to 0.499/unit area ± 0.058 SEM (n = 30 images taken from 10 slices, p < 0.001) (Fig. 1A3). The effect of ghrelin was blocked by the ghrelin receptor antagonist, D-Lys3-GHSR-6 (100 uM) (0.333/unit area ± 0.041 SEM, n = 30 images taken from 10 slices), suggesting the involvement of the ghrelin receptor activation and possible downstream signaling cascades in the induction of ghrelin-mediated changes in dendritic spines." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2572 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |