Annotated protein:Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin-23; Obestatin-13]. Gene symbol: GHRL. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9QYH7
antibody wiki:
SynGO gene info:SynGO data @ GHRL
Ontology domain:Biological Process
SynGO term:regulation of postsynapse organization (GO:0099175)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Berrout L, et al. "Ghrelin promotes reorganization of dendritic spines in cultured rat hippocampal slices" Neurosci Lett. 2012 May 16;516(2):280-4 PMID:22516464
Figure(s):Fig.1
Annotation description:Fig.1: "Ghrelin was applied for 60 min (Fig. 1A3 and C). In control slices, the average spine density was 0.302/unit area ± 0.039 SEM (n = 30 images taken from 10 slices) (Fig. 1A2). Ghrelin (200 nM) increased the average spine density to 0.499/unit area ± 0.058 SEM (n = 30 images taken from 10 slices, p < 0.001) (Fig. 1A3). The effect of ghrelin was blocked by the ghrelin receptor antagonist, D-Lys3-GHSR-6 (100 uM) (0.333/unit area ± 0.041 SEM, n = 30 images taken from 10 slices), suggesting the involvement of the ghrelin receptor activation and possible downstream signaling cascades in the induction of ghrelin-mediated changes in dendritic spines."
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2571
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology