| Annotated protein: | Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor). Gene symbol: GHSR. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O08725 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GHSR |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0098696) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Ribeiro LF, et al. "Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus" Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E149-58 PMID:24367106 |
| Figure(s): | Fig.4, 5, 7 |
| Annotation description: | Ghrelin is a peptide that acts on the GHS-R1a receptor in hippocampal neurons to induce synaptic potentiation. Fig.5: "Ghrelin receptor activation increases the cell-surface trafficking of GluA1-AMPAR mediated by cLTP." Fig.7: "Ghrelin receptor activation triggers changes in GluA1 and stargazin phosphorylation and the PKA and PKC signaling pathways are required for increased GluA1-AMPAR surface expression induced by ghrelin receptor activation in the hippocampus." |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp Western blot |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2570 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |