| Annotated protein: | Synaptotagmin-11 (Synaptotagmin XI) (SytXI). Gene symbol: SYT11. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O08835 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYT11 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Yeo H, et al. "Developmental expression and subcellular distribution of synaptotagmin 11 in rat hippocampus" Neuroscience. 2012 Dec 6;225:35-43 PMID:22960622 |
| Figure(s): | Fig. 6 |
| Annotation description: | Results section. "Ultrastructural localization of Syt11 in rat hippocampal CA1 synapses by immunoelectron microscopy" -Literal: "We finally examined the ultrastructural distribution of Syt11 protein in rat hippocampus by immunogold EM (Fig. 6) ...In axon terminals, Syt11 signals were colocalized with presynaptic vesicles as well as the active zones..." 22/2/2018 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 2566 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |