| Annotated protein: | Neurogranin (Ng) (Protein kinase C substrate 7.5 kDa protein) (RC3) [Cleaved into: NEUG(55-78)]. Gene symbol: NRGN. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q04940 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRGN |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic modulation of chemical synaptic transmission (GO:0099170) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Zhong L, et al. "Neurogranin enhances synaptic strength through its interaction with calmodulin" EMBO J. 2009 Oct 7;28(19):3027-39 PMID:19713936 |
| Figure(s): | Fig.2, 7, 8 |
| Annotation description: | Fig.2: "Ng enhances AMPAR-mediated synaptic transmission in an activity-dependent manner." Fig.7: "Ng occludes LTP" Fig.8: "Ng is required for LTP induction" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Field recordings |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2551 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |