| Annotated protein: | Neurogranin (Ng) (Protein kinase C substrate 7.5 kDa protein) (RC3) [Cleaved into: NEUG(55-78)]. Gene symbol: NRGN. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q04940 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRGN |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic membrane (GO:0045211) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Zhong L, et al. "Neurogranin enhances synaptic strength through its interaction with calmodulin" EMBO J. 2009 Oct 7;28(19):3027-39 PMID:19713936 |
| Figure(s): | Fig.6 |
| Annotation description: | Fig.6: "Ultrastructural organization of Ng in dendritic spines" - "Interestingly, Ng localization at the extrasynaptic membrane (within the spine) reveals a non-uniform distribution, in which there is a minimal concentration midway between the PSD edge and the furthest tangential point (Supplementary Figure 6C), an area within the spine that is well characterized as the endocytic zone (Blanpied et al, 2002; Racz et al, 2004; Lu et al, 2007)." Since localization to endocytic zone is suggested but not shown, I have not used this term. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2550 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |