| Annotated protein: | Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2). Gene symbol: NR3C2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8VII8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NR3C2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic membrane potential (GO:0060078) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Olijslagers JE, et al. "Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors" Eur J Neurosci. 2008 May;27(10):2542-50 PMID:18547242 |
| Figure(s): | Fig.4 |
| Annotation description: | Fig.4: "Corticosterone modulated IA currents via a postsynaptic MR and G protein." - "As established in another set of cells (n = 4), intracellular application of 0.5 mm GDP-β-S did not affect the IA per se but did prevent the corticosterone-induced change in V½ (P < 0.05; Fig. 4D), indicating the involvement of a G protein-dependent pathway coupled to a membrane-located MR. All in all, these data strongly suggest that corticosterone via MRs and G-proteins activates the postsynaptic ERK1/2 pathway in hippocampal cells, thus decreasing IA amplitude. This pathway, however, is not involved in the MR-dependent increase in mEPSC frequency." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2549 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |