Annotated protein:Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1). Gene symbol: NR3C1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P06536
antibody wiki:
SynGO gene info:SynGO data @ NR3C1
Ontology domain:Cellular Component
SynGO term:postsynaptic density, intracellular component (GO:0099092)
Synapse type(s):amygdala, glutamatergic
Annotated paper:Prager EM, et al. "Localization of mineralocorticoid receptors at mammalian synapses" PLoS One. 2010 Dec 15;5(12):e14344 PMID:21179518
Figure(s):Fig.6, 7
Annotation description:Fig.6: "GR and MR labeling at asymmetrical synapses"
- "MR-ir and GR-ir was expressed in pre- and postsynaptic sites. Qualitative examination of asymmetrical synapses revealed both GR-ir and MR-ir (MA1-620 and rMR1-18 1D5) at the PSD (Fig. 6B-D) and MR-ir at the presynaptic terminal (Fig. 6D), compared to the primary antibody omitted PSD (Fig. 6A)."

Fig.7: "Quantitative analysis of labeling at postsynaptic density of asymmetrical synapses"
- "Planned contrasts between the groups revealed a significant difference between the primary antibody omitted control and both MRs and GR (t=10.496; p<.001)."
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2546
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology