| Annotated protein: | D(1B) dopamine receptor (D(5) dopamine receptor) (Dopamine D5 receptor). Gene symbol: DRD5. Taxonomy: Macaca Mulatta (Rhesus Macaque). Uniprot ID: Q95195 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DRD5 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | globus pallidus basal ganglia |
| Annotated paper: | Kliem MA, et al. "Comparative Ultrastructural Analysis of D1 and D5 Dopamine Receptor Distribution in the Substantia Nigra and Globus Pallidus of Monkeys" Adv Behav Biol. 2009 Aug 21;58:239-253 PMID:19750130 |
| Figure(s): | Fig.2 |
| Annotation description: | Figure 2: "Localization of D5 receptor immunoreactivity in GPi and SNr in normal and MPTP-treated monkeys." - "(A-D) illustrate D5 receptor immunolabeling in dendrites (Den), unmyelinated axons (Ax) and terminals (Ter) in GPi (A-B) and SNr (C-D) of normal and MPTP-treated monkeys. Occasional glial labeling is also depicted in the SNr (arrowhead in C). Scale bars: 0.5 μm." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2534 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |