| Annotated protein: | D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor). Gene symbol: DRD4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P30729 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DRD4 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | basal ganglia |
| Annotated paper: | Rivera A, et al. "Expression of D4 dopamine receptors in striatonigral and striatopallidal neurons in the rat striatum" Brain Res. 2003 Oct 31;989(1):35-41 PMID:14519509 |
| Figure(s): | Fig.3 |
| Annotation description: | Fig.3: "Electron photomicrographs showing D4 immunoreactivity in axons, axon terminals and dendritic profiles in the SNr." - "Immunopositive axon terminals were also observed, and some of them established asymmetrical contact with unlabeled dendritic profiles (Fig. 3B). " - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2530 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |