| Annotated protein: | D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor). Gene symbol: DRD4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P30729 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DRD4 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072) |
| Synapse type(s): | neocortex, glutamatergic |
| Annotated paper: | Wang X, et al. "Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex" J Neurosci. 2003 Oct 29;23(30):9852-61 PMID:14586014 |
| Figure(s): | Fig.1, 2, 6 |
| Annotation description: | Fig.1: "Activation of D4 receptors reversibly reduced NMDA receptor currents in acutely dissociated PFC pyramidal neurons. " Fig.2: "Activation of D4 receptors reduced the amplitude of NMDAR-mediated EPSCs in PFC slices but did not change the paired-pulse ratio of NMDAR EPSCs." Fig.6: "Activation of D4 receptors reduced the NMDAR surface expression and increased the NMDAR internalization in a CaMKII-dependent manner. " |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence Whole-cell patch clamp Western blot |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2529 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |