| Annotated protein: | D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor). Gene symbol: DRD4. Taxonomy: Mus musculus (Mouse). Uniprot ID: P51436 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DRD4 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Kwon OB, et al. "Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors" Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15587-92 PMID:18832154 |
| Figure(s): | Fig.3, 4, 5 |
| Annotation description: | Fig.3: "D4R null mice lack NRG-1β and TPS-mediated LTP depotentation" Fig.4: 'Stimulation of D4R, but not D2/D3Rs, depotentiates LTP at SC-CA1 glutamatergic synapses" Fig.5: "Activation of D4R promotes the internalization of GluR1-containing AMPARs in dissociated hippocampal neurons" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2528 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |