| Annotated protein: | D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor). Gene symbol: DRD4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P30729 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DRD4 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | diencephalon, glutamatergic diencephalon, GABAergic |
| Annotated paper: | Good CH, et al. "Dopamine D4 receptor excitation of lateral habenula neurons via multiple cellular mechanisms" J Neurosci. 2013 Oct 23;33(43):16853-64 PMID:24155292 |
| Figure(s): | Fig.6, 7 |
| Annotation description: | Fig.6: "DA increases quantal glutamate release via D4Rs in mLHb neurons. " Fig.7: "DA reduces GABAergic synaptic transmission via D4Rs in mLHb neurons." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2527 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |