| Annotated protein: | D(3) dopamine receptor (Dopamine D3 receptor). Gene symbol: DRD3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P19020 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DRD3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | striatum, glutamatergic |
| Annotated paper: | Sokoloff P, et al. "Direct and indirect interactions of the dopamine D(3) receptor with glutamate pathways: implications for the treatment of schizophrenia" Naunyn Schmiedebergs Arch Pharmacol. 2013 Feb;386(2):107-24 PMID:23001156 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1: "Immunoperoxidase labeling for the D3 receptor in the nucleus accumbens of rat brain" - "Images (a-d) showing that immunoreactivity for D3R, is localized at asymmetric synapses in dendritic spines (ed) in medium-sized spiny neurons of the nucleus accumbens. Note the high density of labeling in, or near, the region of the post-synaptic density at the head of dendritic spines (particularly visible in a sagittal section of a dendritic spine in d), which is juxtaposed to presynaptic terminal profiles (t), containing clear vesicles and forming asymmetric synapses." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Liu et al., (2009) showed that the D3 receptor binds to Ca2+/calmodulin-dependent protein kinase II (CaMKII) in a Ca2+-dependent manner in the glutamatergic-associated post-synaptic densities (PSD)-enriched fraction of accumbal neurons. @ PMID:19217379 |
| SynGO annotation ID: | 2525 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |