| Annotated protein: | D(2) dopamine receptor (Dopamine D2 receptor). Gene symbol: DRD2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P61169 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DRD2 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic modulation of chemical synaptic transmission (GO:0099170) |
| Synapse type(s): | neocortex |
| Annotated paper: | Tseng KY, et al. "Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms" J Neurosci. 2004 Jun 2;24(22):5131-9 PMID:15175382 |
| Figure(s): | Fig.2, 4, 5 |
| Annotation description: | This study shows that DRD2 modulates synaptic transmission via postsynaptic modulation of cell excitability via modulation of NMDARs and AMPARs. Note: the high level term 'postsynaptic modulation of chemical synaptic transmission (GO:0099170)' was selected because the underlying mechanism of increased NTR responses is not explained. Beware: the term 'regulation of postsynaptic neurotransmitter receptor activity (GO:0098962)' was note selected because reserved for proteins that modulate the intrinsic channel properties of NTRs. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2522 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |