| Annotated protein: | D(2) dopamine receptor (Dopamine D2 receptor). Gene symbol: DRD2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P61168 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DRD2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | striatum, GABAergic |
| Annotated paper: | Uchigashima M, et al. "Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures" Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4206-11 PMID:27035941 |
| Figure(s): | Fig.2 |
| Annotation description: | Fig.2: "Expression profiles of dopamine receptors in the striatum" - "In MSNs, the density of cell membrane-attached metal particles for D1R and D2R was comparably high in the soma, dendritic shaft, and dendritic spines (Fig. 2 A-C). In the neuropil, weak immunolabeling for D1R and D2R was also observed in terminals forming symmetric-but not asymmetric-synapses (Fig. 2C)." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2514 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |