| Annotated protein: | D(2) dopamine receptor (Dopamine D2 receptor). Gene symbol: DRD2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P61169 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DRD2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | amygdala, glutamatergic amygdala, GABAergic |
| Annotated paper: | Pinto A, et al. "Ultrastructural analysis of prefrontal cortical inputs to the rat amygdala: spatial relationships to presumed dopamine axons and D1 and D2 receptors" Brain Struct Funct. 2008 Sep;213(1-2):159-75 PMID:18340460 |
| Figure(s): | Fig.6 |
| Annotation description: | Fig.6: "Electron micrographs showing immunoperoxidase labeling for the D2 receptor within dendrites (D2-d in panel a and c), spines (D2-s in panel b), and axon terminals (D2-t in panels d and e) within the ICMs (panels a and d) and BLA (panels b, c, and e) of the AMG" - "The D2R was frequently observed within dendrites (Fig. 6a, c) and spines (Fig. 6b)." - "The D2R was frequently found within axonal profiles (Fig. 6d, e). Some of these formed either symmetric or asymmetric synapses (Fig. 6e) onto spines or distal dendrites." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2509 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |