| Annotated protein: | Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6) (Glutamate receptor beta-2) (GluR beta-2). Gene symbol: GRIK2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P39087 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIK2 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Mulle C, et al. "Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice" Nature. 1998 Apr 9;392(6676):601-5 PMID:9580260 |
| Figure(s): | Fig.4 |
| Annotation description: | Fig.4: "Figure 4: Mossy fibre kainate EPSC cannot be detected in GluR6-/- mice" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2499 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |