| Annotated protein: | Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6) (Glutamate receptor beta-2) (GluR beta-2). Gene symbol: GRIK2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P39087 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIK2 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Pinheiro PS, et al. "Selective block of postsynaptic kainate receptors reveals their function at hippocampal mossy fiber synapses" Cereb Cortex. 2013 Feb;23(2):323-31 PMID:22345355 |
| Figure(s): | Fig.1-3 |
| Annotation description: | The authors show that slow KAR-mediated postsynaptic responses in MF-CA3 synapses are mediated by GluK2/GluK5 heteromers via sensitivity to UBP310, a compound that was first to be selective for GluK1 or GluK3 containing KARs only. Authors show that UBP310 is an antagonist of GluK2/GluK5 heteromers and not of GluK2 homomeric KARs in a heterologous system. Via activity of the UBP310 compound in GluK1 or GluK3 KO animals the action of UBP310 on GluK2/GluK5 heteromers and not GluK1 or GluK3 containing KARs is confirmed. Note: Of Gluk5 is it known that it is unable to form functional homopentameric KARs. It is known to form GluK2/GluK5 heteropentamers that represent a large portion of all KAR-mediated responses in the mammalian brain. |
| Evidence tracking, Biological System: | Intact tissue Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Electrophysiology (generic) |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Postsynaptic kainate currents evoked in CA3 neurons by a train of stimulation of the mossy fibre system is absent in mice lacking the kainate-receptor subunit GluR6. @ PMID:9580260 |
| SynGO annotation ID: | 2494 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |