| Annotated protein: | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) (ZnT-1). Gene symbol: SLC30A1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62720 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC30A1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Sindreu C, et al. "Zinc transporter-1 concentrates at the postsynaptic density of hippocampal synapses" Mol Brain. 2014 Mar 7;7:16 PMID:24602382 |
| Figure(s): | Fig. 1-3 |
| Annotation description: | Results Section: "ZnT1 concentrates at the postsynaptic density" -Literal: "Particle distribution along the axis perpendicular to the synaptic junction revealed a main peak on the cytoplasmic side of the postsynaptic membrane (7.1 ± 0.8 nm from the membrane; n = 339 particles and 132 synapses) (Figure 2F)." "The results indicate that ZnT1 concentrates in the postsynaptic membrane of hippocampal synapses,...." 13/2/2018 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 2488 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |