| Annotated protein: | Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4). Gene symbol: GRIA4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P19493 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIA4 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | thalamus, glutamatergic |
| Annotated paper: | Mineff EM, et al. "Differential synaptic distribution of AMPA receptor subunits in the ventral posterior and reticular thalamic nuclei of the rat" Neuroscience. 2000;101(4):969-82 PMID:11113346 |
| Figure(s): | Fig.5 |
| Annotation description: | Fig. 5: "Electron micrographs showing immunogold staining for GluR4 in the reticular nucleus" - "Gold particles coding for GluR2/3 and GluR4 exhibited similar overall distributions .... Labeling was concentrated over the postsynaptic density, postsynaptic membranes, and synaptic cleft of a large fraction of asymmetric synapses" - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2487 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |