| Annotated protein: | Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4). Gene symbol: GRIA4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9Z2W8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIA4 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | thalamus, glutamatergic |
| Annotated paper: | Paz JT, et al. "A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy" Nat Neurosci. 2011 Aug 21;14(9):1167-73 PMID:21857658 |
| Figure(s): | Fig.3 |
| Annotation description: | Spontaneous EPSCs in thalamic nRT neurons in Gria4 KO mice have a lower amplitude and show a two fold slower decay time. This points to a postsynaptic role in membrane potential regulation of GluA4. GluA4 is mostly expressed in the thalamus, particularly in nRT, where it is the predominant AMPA receptor subunit at the CT-nRT synapse. GluA4-containing receptors have the fastest desensitization rate compared with other subunits expressed in the nRT. Thus, the loss of the GluA4 subunit is consistent with the reduced amplitude and the slower decay kinetics of sEPSCs in nRT neurons. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2486 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |