Annotated protein:Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3). Gene symbol: GRIA3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P19492
antibody wiki:
SynGO gene info:SynGO data @ GRIA3
Ontology domain:Cellular Component
SynGO term:integral component of postsynaptic density membrane (GO:0099061)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Moga DE, et al. "Glutamate receptor subunit 3 (GluR3) immunoreactivity delineates a subpopulation of parvalbumin-containing interneurons in the rat hippocampus" J Comp Neurol. 2003 Jul 14;462(1):15-28 PMID:12761821
Figure(s):Fig.9
Annotation description:Fig.9: "Electron micrographs of CA1 rat hippocampal sections demonstrating immunogold labeling for GluR3 in asymmetric axospinous synapses."
- Literal: "CA1 neuropil displayed asymmetric synapses immunoreactive for GluR3, which was localized throughout both the postsynaptic density (PSD) and the synaptic cleft (Fig. 9)."

Note: "The specificity of MAb:3B3 for GluR3 in brain tissue sections was demonstrated by preincubating MAb:3B3 with the GluR1, GluR2, and GluR3 fusion proteins. The GluR3 fusion protein entirely blocked the immunoreactivity of MAb:3B3 in cortical sections (Fig. 2; only CA1 shown), while this immunoreactivity was not altered with the GluR1 and GluR2 fusion proteins compared to controls in which the fusion proteins were omitted."

- Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2484
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology