| Annotated protein: | Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3). Gene symbol: GRIA3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9Z2W9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIA3 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | Parallel fibre (cerebellum -> Purkinje-cell) |
| Annotated paper: | Gutierrez-Castellanos N, et al. "Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3" Neuron. 2017 Jan 18;93(2):409-424 PMID:28103481 |
| Figure(s): | Fig.2-5 |
| Annotation description: | This paper shows a novel GluR3 dependent mechanism of LTP in the cerebellum. GluR3 is shown to mediate enhanced postsynaptic responses in PF to PC synapses. The enhancement of responses is not mediated by trafficking (more AMPARs in the PSD membrane as shown for the hippocampal CA1-CA3 synapse), but via cAMP dependent change in the single channel concuctance of Glur3 containing receptors. Overall it can be concluded that GluR3 mediates membrane potential changes in the postsynaptic membrane. Fig.2: "GluA3 Is Required for PF-PC LTP, but Not LTD" Fig.3: "Rising cAMP Levels Produce GluA3-Dependent Postsynaptic Potentiation" Fig.4: "Rising cAMP Levels Produce GluA3-Dependent Synaptic Potentiation without AMPAR Trafficking" Fig.5: "GluA3 Plasticity Occurs through cAMP-Dependent Changes of Single-Channel Conductance and Open Probability" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2483 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |