| Annotated protein: | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c). Gene symbol: ADAM10. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q10743 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADAM10 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Marcello E, et al. "Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity" J Neurosci. 2007 Feb 14;27(7):1682-91 PMID:17301176 |
| Figure(s): | Fig.2, 4, 5 |
| Annotation description: | Fig.2: colocalization of ADAM10 with PSD-95 asnd Shank, not with synaptophysin. Fig.4-5: ADAM10 translocates into dendritic spine upon NMDA-R activation. Note: ADAM10 has TM domain, but exeriments do not show membrane localization. Therefore, only **postsynapse** annotation is made. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| Additional literature: | similar finding @ PMID:21123580 |
| SynGO annotation ID: | 248 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |