| Annotated protein: | Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2). Gene symbol: GRIA2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P23819 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIA2 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Zhou Z, et al. "The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning" Nat Neurosci. 2018 Jan;21(1):50-62 PMID:29230056 |
| Figure(s): | Fig.2-4 |
| Annotation description: | There is a ton of experimental evidence for Gria2; GluR2 as a LGIC that is located at the PSD of glutamatergic synapses and is involved in membrane potential regulation. This paper is a recent example of this notion. Background: hippocampal LTP is effectuated by a an increase in the number of AMPARs in the PSD membrane that effectuate an enhanced postsynaptic response to presynaptic NT release. In this paper the authors show that localization of more AMPARs during LTP is dependent on the cytoplasmic tail of the Gria2; GluR2. Basal properties of synaptic transmission is unaffected in the Gria2; GluR2 mutant mice. Fig.2: "Absence of NMDAR-LTP, but intact NMDAR-LTD, in GluA1C2KI mice." Fig.3: "Absence of NMDAR-LTD, but intact mGluR-LTD, in GluA2C1KI mice." Fig.4: "Restoration of both LTP and LTD in GluA1C2KI;GluA2C1KI double CTD replacement mice." [Fig.5: "Impaired glycine- and NMDA-induced AMPAR surface delivery and removal in GluA1C2KI and GluA2C1KI cultured neurons, respectively."] [Fig.6: "Impaired glycine- and NMDA-induced AMPAR surface delivery and removal in GluA1C2KI and GluA2C1KI hippocampal slices, respectively."] |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2479 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |