| Annotated protein: | Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48). Gene symbol: PTPRD. Taxonomy: Homo sapiens (Human). Uniprot ID: P23468 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRD |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Yim YS, et al. "Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases" Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4057-62 PMID:23345436 |
| Figure(s): | Fig 4 |
| Annotation description: | Slitrks interact with PTPRD. Knock-down of PTPRD reduces inhibitory synapse formation. 19/2/2018 Pim - PTPRD is a known presynaptic protein (see ticket #2248). It is shown to mediate cell-cell adhesion with SLITRK1,2,3 in a cell-adhesion assay (Fig.4A+B). SLITRK1,2,3 expressed in HEKcells is able to induce PTPRD mediated clustering of presynaptic (Synapsin1, VGLUT1, GAD67) but not postsynaptic (PSD-95) markers (Fig.4C+D). PTPRD is mediates only the presynaptic differentiation of Glutamatergic synapses via SLITRK1 and 2 (not SLITRK3).Note that PTPRD KD interferes with presynaptic differentiation by SLITRK1, SLITRK2 and SLITRK3 of GABAergic synapses only. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| Additional literature: | PTPRD is a presynaptic binding partner for Slitrk3. Slitrk3 requires PTPRD for induction of inhibitory presynaptic differentiation. @ PMID:22286174 |
| SynGO annotation ID: | 2478 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |