| Annotated protein: | Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma). Gene symbol: PTPRS. Taxonomy: Homo sapiens (Human). Uniprot ID: Q13332 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRS |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Yim YS, et al. "Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases" Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4057-62 PMID:23345436 |
| Figure(s): | Fig 4 |
| Annotation description: | Slitrks interact with PTPRS. Knock-down of PTPRS reduces excitatory synapse formation. 19/2/2018 Pim - PTPRS is a known presynaptic protein (see ticket #2246). It is shown to mediate cell-cell adhesion with SLITRK1,2,3 in a cell-adhesion assay (Fig.4A+B). SLITRK1,2,3 expressed in HEKcells is able to induce PTPRS mediated clustering of presynaptic (Synapsin1, VGLUT1, GAD67) but not postsynaptic (PSD-95) markers (Fig.4C+D). Note that PTPRS KD interferes with presynaptic differentiation by SLITRK1 and SLITRK2 of Glutamatergic synapses only. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2477 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |