| Annotated protein: | Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Leukocyte common antigen-related protein-tyrosine phosphatase 2) (LAR-PTP2) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma). Gene symbol: PTPRS. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q64605 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRS |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Choi Y, et al. "SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development" Sci Rep. 2016 May 26;6:26676 PMID:27225731 |
| Figure(s): | fig 4, 5 |
| Annotation description: | Splice inserts in the Ig domains of LAR, PTPδ, and PTPσ differentially regulate SALM5 binding. LAR-RPTPs mediate SALM5-dependent presynaptic differentiation. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2472 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |