Annotated protein: | Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5). Gene symbol: CACNG5. Taxonomy: Homo sapiens (Human). Uniprot ID: Q9UF02 |
antibody wiki: | |
SynGO gene info: | SynGO data @ CACNG5 |
Ontology domain: | Biological Process |
SynGO term: | regulation of postsynaptic neurotransmitter receptor activity (GO:0098962) |
Synapse type(s): | olfactory bulb, glutamatergic |
Annotated paper: | Kato AS, et al. "AMPA receptor subunit-specific regulation by a distinct family of type II TARPs" Neuron. 2008 Sep 25;59(6):986-96 PMID:18817736 |
Figure(s): | Figure 1-6, 7, 8 |
Annotation description: | TARP γ-5 is an integral membrane protein belonging to the type II family of TARPs. Fig.1: TARP γ-5 is shown to interact with AMPARs Fig.2: "γ-5 Modulates GluR2 but Not GluR1 Homomeric AMPA Receptors" (HEK cells) Fig.3: "Subunit-Specific Modulation of GluR Homomers by Type II TARPs" (HEK cells) Fig.4: "γ-5 Accelerates Deactivation and Both Accelerates and Enhances the Extent of Desensitization of GluR2iR-Containing AMPA Receptors" (HEK cells+ correlation of expression level and native AMPAR properties) Fig.5: "γ-5 Lowers the Affinity of Glutamate on GluR2R-Containing AMPA Receptors" (HEK cells+ correlation of expression level and native AMPAR properties) Fig.7: "γ-5 Preferentially Regulates AMPA Receptor Heteromers Composed of GluR2/3 Subunits" (HEK cells) Fig.8: "Transfection of γ-5 into Neuronal AMPA Receptors Modifies Their Gating Properties" (dissociated cerebral cortex neurons) |
Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
Evidence tracking, Protein Targeting: | Over-expression |
Evidence tracking, Experiment Assay: | Electrophysiology (generic) IP + WB/MSMS |
Annotator(s): | Hana Goldschmidt (ORCID:0000-0002-5676-366X) Richard Huganir (ORCID:0000-0001-9783-5183) |
Lab: | Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA and Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA |
SynGO annotation ID: | 2470 |
Dataset release (version): | 20231201 |
View annotation as GO-CAM model: |