| Annotated protein: | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR). Gene symbol: PTPRF. Taxonomy: Homo sapiens (Human). Uniprot ID: P10586 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRF |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Li Y, et al. "Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion" Cell Rep. 2015 Sep 8;12(10):1618-30 PMID:26321637 |
| Figure(s): | fig 2, 3 |
| Annotation description: | The meB Splice Insert in Ig Domains of LAR-RPTPs Is Sufficient for SALM3 Binding, whereas meA Is Modulatory. SALM3-Dependent Presynaptic Differentiation Requires All Three LAR-RPTPs. 2/3/2018 PIm - Adhesion term is supported by cell-adhesion assays in Fig.2 and 3. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| Additional literature: | Soluble LAR reduces NGL-3-induced presynaptic differentiation. LAR in HEK293T cells induces postsynaptic differentiation These results support that LAR is presynaptically localized. @ PMID:19252495 Ticket #2215 LRFN4 is localized postsynaptically. @ PMID:20410109 |
| SynGO annotation ID: | 2467 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |