| Annotated protein: | Neural F box protein NFB42. Gene symbol: FBXO2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9Z1X8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FBXO2 |
| Ontology domain: | Cellular Component |
| SynGO term: | extrinsic component of postsynaptic membrane (GO:0098890) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Kato A, et al. "Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination" Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5600-5 PMID:15809437 |
| Figure(s): | Fig.1, 3 |
| Annotation description: | Fig.1: "Identification of Fbx2 as a NR1-NTD-Binding Partner." - Fbx2 binds the extracellular domain of NR1. Fig.3: "Fbx2 localizes to the somatodendritic region and to synaptic spines. " - "NR1 and Fbx2 partly colocalize in somatodendritic regions (Fig. 3). Furthermore, some punctate Fbx2 staining colocalized with NR1 and/or PSD95 in synaptic spines. Synaptophysin puncta were often juxtaposed to Fbx2 puncta but were rarely overlapping, consistent with a postsynaptic function for Fbx2." |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Protein-protein interaction (generic) |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2466 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |