| Annotated protein: | protein-tyrosine-phosphatase (EC 3.1.3.48). Gene symbol: PTPRD. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: M0RB22 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRD |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Kwon SK, et al. "Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation" J Biol Chem. 2010 Apr 30;285(18):13966-78 PMID:20139422 |
| Figure(s): | Fig.7 |
| Annotation description: | PTPRD interacts with NGL-3 through their first two FNIII domains. 19/2/2018 Pim - PTPRD is a know presynaptic protein (see ticket #2248). It is shown to mediate cell-cell adhesion with NGL-3 in a cell-adhesion assay (Fig.7A+E). PTPRD expressed in HEKcells is able to cluster postsynaptic NGL-3 (Fig.7C). PTPRD is not able to induce postsynaptic differentiation (Fig.8). |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2465 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |