| Annotated protein: | Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Leukocyte common antigen-related protein-tyrosine phosphatase 2) (LAR-PTP2) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma). Gene symbol: PTPRS. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q64605 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRS |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Kwon SK, et al. "Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation" J Biol Chem. 2010 Apr 30;285(18):13966-78 PMID:20139422 |
| Figure(s): | fig 7, 8 |
| Annotation description: | PTPRS interacts with NGL-3 through their first two FNIII domains. The FN1-2 domain of PTPRS induces postsynaptic PSD-95 clustering. 19/2/2018 Pim - PTPRS is a know presynaptic protein (see ticket #2246). It is shown to mediate cell-cell adhesion with NGL-3 in a cell-adhesion assay (Fig.7A+E). PTPRS expressed in HEKcells is able to cluster postsynaptic NGL-3 (Fig.7C). PTPRS is able to induce postsynaptic differentiation (Fig.8). |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2464 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |