| Annotated protein: | Netrin-G2 (Laminet-2). Gene symbol: NTNG2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R4F1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NTNG2 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Kim S, et al. "NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation" Nat Neurosci. 2006 Oct;9(10):1294-301 PMID:16980967 |
| Figure(s): | fig 1, 2, 4, 6, Suppl.3 |
| Annotation description: | LRRC4 interacts with netrin-G CAMs through its ectodomain in an isoform-specific manner. 4/3/2018 Pim - Netrin-G2; NTNG2 is localized at the presynaptic side (see ticket #2322) - LRRC4 is located at the postsynaptic side (Fig.2; see ticket #2219) - Adhesion between these proteins is tested in Fig.1C - Literal: "It is not known whether NGL and netrin-G mediate cell adhesion. L cells transiently expressing NGL-1 and NGL-2 selectively aggregated with cells expressing netrin-G1 and netrin-G2, respectively (Supplementary Fig. 3 online), suggesting that the association between NGL and netrin-G mediates cell adhesion in an isoform-specific manner." |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2462 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |