| Annotated protein: | Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1). Gene symbol: NCAM1. Taxonomy: Gallus gallus (Chicken). Uniprot ID: P13590 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NCAM1 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Annotated paper: | Rao Y, et al. "Mechanism of homophilic binding mediated by the neural cell adhesion molecule NCAM. Evidence for isologous interaction" J Biol Chem. 1994 Nov 4;269(44):27540-8 PMID:7961669 |
| Figure(s): | fig 4-10 |
| Annotation description: | Domain 3 of NCAM-conjugated Covaspheres were bound to the substratecoated NCAM. Domain 3 of NCAM-conjugated Covaspheres were bound to substrate-coated domain 3 of NCAM protein. NCAM-transformed cells were attached to substrate-coated peptides. 6/3/2018 Pim - NCAM1 is a known 'integral component of presynaptic membrane (GO:0099056)' (see ticket #2224) and integral component of postsynaptic membrane (GO:0099055) (see ticket #2406). - - |
| Evidence tracking, Biological System: | Non-neuronal tissue Cell-free system |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Microscopy (generic) |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| Additional literature: | NCAM IgI-IgII form homophilic binding complex in crystallography. @ PMID:10802736 |
| SynGO annotation ID: | 2459 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |