| Annotated protein: | Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3). Gene symbol: LRRC4B. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P0CC10 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRRC4B |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Woo J, et al. "Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses" Nat Neurosci. 2009 Apr;12(4):428-37 PMID:19252495 |
| Figure(s): | fig 1, 4, 6, 7 |
| Annotation description: | LRRC4b expressed in non-neural cells induces functional presynaptic differentiation in contacting axons. Direct aggregation of LRRC4b on the surface of dendrites induces coclustering of excitatory postsynaptic proteins. LRRC4b interacts with LAR. Soluble LAR reduces LRRC4b-induced presynaptic differentiation. 19/2/2018 Pim - Fig.6 features a cell-cell-aggregation assay that demonstrates the adhesive properties of LRRC4b. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2457 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |