| Annotated protein: | Leucine-rich repeat-containing protein 4 (Netrin-G2 ligand) (NGL-2). Gene symbol: LRRC4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q45R42 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRRC4 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Kim S, et al. "NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation" Nat Neurosci. 2006 Oct;9(10):1294-301 PMID:16980967 |
| Figure(s): | fig 1, 2, 4, 6 |
| Annotation description: | LRRC4 interacts with netrin-G CAMs through its ectodomain in an isoform-specific manner. LRRC4 localizes to the postsynaptic side of excitatory synapses. LRRC4 expression in heterologous cells induces functional presynaptic differentiation in contacting neurites. Direct aggregation of LRRC4 on the dendritic surface induces clustering of excitatory postsynaptic proteins. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2456 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |