| Annotated protein: | Leucine-rich repeat and fibronectin type-III domain-containing protein 5. Gene symbol: LRFN5. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D4A1J9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRFN5 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Choi Y, et al. "SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development" Sci Rep. 2016 May 26;6:26676 PMID:27225731 |
| Figure(s): | fig 1, 3, 5 |
| Annotation description: | SALM5 interacts with LAR in cell aggregation assays. SALM5 directly interacts with LAR. Soluble LAR inhibits SALM5-dependent synapsin I clustering. |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue Cell-free system |
| Evidence tracking, Protein Targeting: | Over-expression Antagonist / agonist Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Protein-protein interaction (generic) |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| Additional literature: | SALM5 form homophilic complexes across cell junctions. @ PMID:18227064 |
| SynGO annotation ID: | 2455 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |