| Annotated protein: | Leucine-rich repeat and fibronectin type-III domain-containing protein 4. Gene symbol: LRFN4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80XU8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRFN4 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Mah W, et al. "Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation" J Neurosci. 2010 Apr 21;30(16):5559-68 PMID:20410109 |
| Figure(s): | fig 1, 2, 3, 5, 6 |
| Annotation description: | LRFN4 expressed in nonneural cells induce presynaptic differentiation in contacting axons. LRFN4 induce excitatory and inhibitory presynaptic protein clustering. LRFN4 induce the uptake of synaptotagmin lumenal domain antibodies in contacting axons of cocultured neurons. Overexpression of LRFN4 in cultured neurons increases the amount of presynaptic contacts. Overexpression of LRFN4 in cultured neurons increases the amount of excitatory and inhibitory presynaptic contacts. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| Additional literature: | Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development. Data in Figure 1 supports trans-cellular adhesion between SALM3 and LAR-RPTPs. @ PMID:26321637 |
| SynGO annotation ID: | 2454 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |