| Annotated protein: | Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (Synaptic adhesion-like molecule 4). Gene symbol: LRFN3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: B0BNK7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRFN3 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Seabold GK, et al. "The SALM family of adhesion-like molecules forms heteromeric and homomeric complexes" J Biol Chem. 2008 Mar 28;283(13):8395-405 PMID:18227064 |
| Figure(s): | fig 6, 7 |
| Annotation description: | LRFN3 form homophilic trans-cellular associations in coculture assays. LRFN3 was localized largely to the cell membrane of neuronal processes (Fig. 7). At synapses, these included both the synaptic and extrasynaptic membranes on both presynaptic and postsynaptic sides, as well as the cell membrane of other structures such as neuron somas (Fig. 7D) and myelinated axons (Fig. 7H). In many cases, plasma membrane-associated gold could be found on both sides of adjacent membrane appositions (Fig. 7, A-D, F, and G). |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2453 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |